The WDR24 Polyclonal Antibody (PAC062775) is a valuable tool for researchers studying the WDR24 protein, a component of the WD repeat-containing protein complex involved in various cellular processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By recognizing and binding to the WDR24 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in molecular biology and cellular signaling pathways.WDR24 is a key player in cellular functions such as protein degradation, gene expression regulation, and cell cycle progression.
Its involvement in these processes underscores its importance in basic biology research and its potential relevance to human diseases. By further elucidating the role of WDR24 in cellular pathways, researchers can gain insights into potential therapeutic targets for conditions such as cancer, genetic disorders, and neurodegenerative diseases. The WDR24 Polyclonal Antibody is a valuable tool for advancing our understanding of WDR24's functions and its implications in disease mechanisms.
Antibody Name:
WDR24 Antibody (PACO62775)
Antibody SKU:
PACO62775
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human GATOR complex protein WDR24 protein (1-298AA)
IHC image of PACO62775 diluted at 1:200 and staining in paraffin-embedded human ovarian tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
As a component of the GATOR subcomplex GATOR2, functions within the amino acid, sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid, sensors SESN2 and CASTOR1. In addition to its role in regulation of the TORC1 complex, promotes the acid, fication of lysosomes and facilitates autophagic flux.
Synonyms:
GATOR complex protein WDR24 (WD repeat-containing protein 24), WDR24, C16orf21
UniProt Protein Function:
WDR24: Belongs to the WD repeat WDR24 family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 16p13.3
