UniProt Protein Function: | WDFY3: 2 isoforms of the human protein are produced by alternative splicing.Protein type: Lipid-binding; Nuclear envelope; Membrane protein, peripheral; TransferaseChromosomal Location of Human Ortholog: 4q21.23Cellular Component: PML body; nuclear membrane; extrinsic to membrane; cytoplasm; autophagic vacuole; nuclear envelope; inclusion bodyMolecular Function: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; protein binding; metal ion binding; phosphatidylinositol bindingBiological Process: endosome transport; positive regulation of macroautophagy |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. [provided by RefSeq, May 2010] |
UniProt Code: | Q8IZQ1 |
NCBI GenInfo Identifier: | 156230428 |
NCBI Gene ID: | 23001 |
NCBI Accession: | AAI48299.1 |
UniProt Secondary Accession: | Q8IZQ1,Q4W5K5, Q6P0Q5, Q8N1T2, Q8NAV6, Q96BS7, Q96D33 Q96N85, Q9Y2J7 |
UniProt Related Accession: | Q8IZQ1 |
Molecular Weight: | 393,367 Da |
NCBI Full Name: | WD repeat and FYVE domain containing 3 |
NCBI Synonym Full Names: | WD repeat and FYVE domain containing 3 |
NCBI Official Symbol: | WDFY3Â Â |
NCBI Official Synonym Symbols: | ALFY; ZFYVE25Â Â |
NCBI Protein Information: | WD repeat and FYVE domain-containing protein 3; autophagy-linked FYVE protein |
UniProt Protein Name: | WD repeat and FYVE domain-containing protein 3 |
UniProt Synonym Protein Names: | Autophagy-linked FYVE protein; Alfy |
Protein Family: | WD repeat and FYVE domain-containing protein |
UniProt Gene Name: | WDFY3Â Â |
UniProt Entry Name: | WDFY3_HUMAN |