The VPS33A Polyclonal Antibody (PAC013192) is a valuable tool for researchers studying VPS33A, a protein involved in membrane trafficking and vesicle fusion processes within cells. This antibody, produced in rabbits, demonstrates high specificity and sensitivity for detecting VPS33A in human samples, particularly in Western blot experiments.VPS33A is a key component of the homotypic fusion and protein sorting (HOPS) complex, essential for the trafficking of proteins to their correct destinations within the cell. Dysregulation of VPS33A has been linked to various human diseases, including neurological disorders and lysosomal storage diseases.
By using this antibody to study VPS33A, researchers can gain valuable insights into its function and potential therapeutic applications in these conditions.Overall, the VPS33A Polyclonal Antibody is a reliable tool for investigating the role of VPS33A in cellular processes and disease pathology, making it a valuable asset for research in cell biology, neurology, and lysosomal storage disorders.
vacuolar protein sorting 33 homolog A (S. cerevisiae);VPS33A;FLJ22395;FLJ23187 ;
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This gene encodes a tethering protein and a core subunit of the homotypic fusion and protein sorting (HOPS) complex. The HOPS complex and a second endosomal tethering complex called the class C core vacuole/endosome tethering (CORVET) complex, perform diverse functions in endocytosis including membrane tethering, RabGTPase interaction, activation and proofreading of synaptic-soluble N-ethylmaleimide-sensitive factor attachment receptor (SNARE) assembly to drive membrane fusion, and endosome-to-cytoskeleton attachment. The HOPS complex controls endosome maturation as well as endosome traffic to the lysosome. This complex is essential for vacuolar fusion and is required for adaptor protein complex 3-dependent transport from the golgi to the vacuole. The encoded protein belongs to the Sec1/Munc18 (SM) family of SNARE-mediated membrane fusion regulators. Naturally occurring mutations in this gene are associated with a novel mucopolysaccharidosis-like disease. [provided by RefSeq, Apr 2017]
