The VKORC1L1 Polyclonal Antibody (PAC037906) is a valuable tool for researchers studying VKORC1L1, a key enzyme involved in the vitamin K cycle and blood coagulation. This antibody, developed specifically for human samples, is raised in rabbits and validated for use in Western blot applications. Its high reactivity with the VKORC1L1 protein enables accurate detection and analysis in a variety of cell types, making it an excellent choice for investigations in areas such as biochemistry and hematology.VKORC1L1 is essential for the activation of vitamin K-dependent clotting factors and is therefore crucial for proper blood coagulation.
Research on VKORC1L1 is important for understanding the mechanisms behind blood clotting disorders and for developing new therapies for conditions such as thrombosis and hemophilia. The VKORC1L1 Polyclonal Antibody provides a reliable tool for studying the role of this enzyme in health and disease, offering insights that may contribute to the advancement of personalized medicine approaches in the future.
Antibody Name:
VKORC1L1 Antibody (PACO37906)
Antibody SKU:
PACO37906
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Vitamin K epoxide reductase complex subunit 1-like protein 1 protein (38-91AA)
Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO37906 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human stomach tissue using PACO37906 at dilution of 1:100.
Background:
Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins.
Synonyms:
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1-like protein 1) (EC 1.17.4.4), VKORC1L1
UniProt Protein Function:
VKORC1L1: Belongs to the VKOR family.Protein type: EC 1.1.4.1; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 7q11.21Cellular Component: endoplasmic reticulum membraneMolecular Function: vitamin-K-epoxide reductase (warfarin-sensitive) activityBiological Process: peptidyl-glutamic acid carboxylation; vitamin K metabolic process
