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VKORC1 Antibody (PACO59013)

SKU:
PACO59013
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • VKORC1 Antibody PACO59013
  • VKORC1 Antibody PACO59013
€339
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Description

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VKORC1 Antibody (PACO59013)

The VKORC1 Polyclonal Antibody (PACO59013) is a valuable tool for researchers studying the Vitamin K epoxide reductase complex 1 (VKORC1) protein. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the VKORC1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for investigations in the fields of coagulation and vitamin K metabolism.

VKORC1 is a key enzyme involved in the vitamin K cycle, playing a crucial role in the regulation of blood clotting. Mutations in the VKORC1 gene have been associated with various coagulation disorders, making it a target of interest in research on cardiovascular diseases and thrombotic conditions. By studying the function and regulation of VKORC1, researchers can gain important insights into the mechanisms underlying these diseases, potentially leading to the development of novel therapeutic strategies.

Antibody Name:VKORC1 Antibody (PACO59013)
Antibody SKU:PACO59013
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:Human
Immunogen:Recombinant Human Vitamin K epoxide reductase complex subunit 1 protein (30-74AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageIHC image of PACO59013 diluted at 1:200 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Product ImageIHC image of PACO59013 diluted at 1:200 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.
Synonyms:Vitamin K epoxide reductase complex subunit 1 (EC 1.17.4.4) (Vitamin K1 2,3-epoxide reductase subunit 1), VKORC1, VKOR
UniProt Protein Function:Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.
NCBI Summary:This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane. Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting enzymes. Allelic variation in this gene is associated with vitamin k-dependent clotting factors combined deficiency of 2, and increased resistance or sensitivity to warfarin, an inhibitor of vitamin K epoxide reductase. Pseudogenes of this gene are located on chromosomes 1 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
UniProt Code:Q9BQB6
NCBI GenInfo Identifier:62511226
NCBI Gene ID:79001
NCBI Accession:Q9BQB6.1
UniProt Secondary Accession:Q9BQB6,Q6UX90, Q7Z2R4, A6NIQ6, B2R4Z6,
UniProt Related Accession:Q9BQB6
Molecular Weight:9,875 Da
NCBI Full Name:Vitamin K epoxide reductase complex subunit 1
NCBI Synonym Full Names:vitamin K epoxide reductase complex subunit 1
NCBI Official Symbol:VKORC1  
NCBI Official Synonym Symbols:VKOR; MST134; MST576; VKCFD2; EDTP308  
NCBI Protein Information:vitamin K epoxide reductase complex subunit 1
UniProt Protein Name:Vitamin K epoxide reductase complex subunit 1
UniProt Synonym Protein Names:Vitamin K1 2,3-epoxide reductase subunit 1
Protein Family:Vitamin K epoxide reductase complex
UniProt Gene Name:VKORC1  
ELISA Kits
Human VKOR / Vitamin K epoxide reductase complex subunit 1 ELISA Kit
Human Vitamin K epoxide reductase complex subunit 1 (VKORC1) ELISA Kit
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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