VAMP1 Antibody (PACO20848)
- SKU:
- PACO20848
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
VAMP1 Antibody (PACO20848)
The VAMP1 Polyclonal Antibody (PAC020848) is a valuable tool for researchers studying VAMP1, a key protein involved in membrane fusion and neurotransmitter release. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blotting applications. By binding specifically to the VAMP1 protein, this antibody enables precise detection and analysis in various cell types, making it ideal for investigations in neuroscience and cell biology.VAMP1, also known as synaptobrevin-1, plays a crucial role in synaptic vesicle exocytosis and neurotransmission in the brain. Its involvement in these physiological processes makes it a promising target for research on neurodegenerative disorders, synaptic dysfunction, and neurological diseases.
Understanding the function of VAMP1 is essential for developing therapeutic strategies that target synaptic transmission and communication in the central nervous system.With its high specificity and sensitivity, the VAMP1 Polyclonal Antibody (PAC020848) is a reliable tool for studying the function and regulation of VAMP1 in physiological and pathological contexts. Researchers can confidently use this antibody to enhance their understanding of synaptic vesicle fusion and neurotransmitter release, paving the way for new insights into brain function and disease mechanisms.
| Antibody Name: | VAMP1 Antibody (PACO20848) |
| Antibody SKU: | PACO20848 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human VAMP1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20848(VAMP1 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 12%SDS-PAGE,Lysate: 40 μgPrimary antibody: PACO20848(VAMP1 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 20 seconds. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20848(VAMP1 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. |
| Synonyms: | vesicle-associated membrane protein 1 (synaptobrevin 1) |
| UniProt Protein Function: | VAMP1: Involved in the targeting and/or fusion of transport vesicles to their target membrane. Belongs to the synaptobrevin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 12p Cellular Component: cell junction; cell surface; cytosol; integral to plasma membrane; mitochondrial outer membrane; synaptic vesicle membrane; terminal button Molecular Function:protein binding; SNAP receptor activity; SNARE binding Biological Process: vesicle fusion Disease: Spastic Ataxia 1, Autosomal Dominant |
| NCBI Summary: | Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014] |
| UniProt Code: | P23763 |
| NCBI GenInfo Identifier: | 135093 |
| NCBI Gene ID: | 6843 |
| NCBI Accession: | P23763.1 |
| UniProt Secondary Accession: | P23763,O75468, Q15857, Q6FG94, Q8IVC9, A8MVP3, D3DUR3 |
| UniProt Related Accession: | P23763 |
| Molecular Weight: | 12,658 Da |
| NCBI Full Name: | Vesicle-associated membrane protein 1 |
| NCBI Synonym Full Names: | vesicle associated membrane protein 1 |
| NCBI Official Symbol: | VAMP1Â Â |
| NCBI Official Synonym Symbols: | SYB1; SPAX1; VAMP-1Â Â |
| NCBI Protein Information: | vesicle-associated membrane protein 1 |
| UniProt Protein Name: | Vesicle-associated membrane protein 1 |
| UniProt Synonym Protein Names: | Synaptobrevin-1 |
| Protein Family: | Vesicle-associated membrane protein |
| UniProt Gene Name: | VAMP1Â Â |
| UniProt Entry Name: | VAMP1_HUMAN |
| Antibodies |
| Anti-VAMP1 Antibody (CAB8877) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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