The UGT2B7 Polyclonal Antibody (CAB1693) is a valuable tool for researchers studying drug metabolism and detoxification processes. This antibody, raised in rabbits, targets the UGT2B7 protein, an important enzyme involved in glucuronidation reactions in the liver. It is highly reactive with human samples and has been validated for use in Western blot applications.UGT2B7 is a key player in the phase II metabolism of a wide range of drugs and xenobiotics, helping to facilitate their elimination from the body.
Variations in UGT2B7 activity can impact drug efficacy and toxicity, making it a crucial target for pharmacogenomic studies. This antibody allows for the specific detection and analysis of UGT2B7 levels in various tissues and cell types, providing valuable insights into drug metabolism pathways and enhancing our understanding of personalized medicine approaches.
Product Name:
UGT2B7 Rabbit Polyclonal Antibody
SKU:
CAB1693
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-351 of human UGT2B7 (NP_001065.2).
The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
7364
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using UGT2B7 Rabbit pAb (CAB1693) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
