The UFSP2 Polyclonal Antibody (PAC013074) is a valuable tool for researchers studying UFSP2, a protein known for its role in the regulation of immune responses. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the UFSP2 protein, it allows for the detection and analysis of UFSP2 in various cell types, making it a versatile option for studies in immunology and cancer research.UFSP2 plays a crucial role in immune regulation, making it a key player in maintaining immune homeostasis and controlling inflammatory responses.
Its involvement in immune function modulation positions it as a promising target for research into conditions such as cancer, autoimmune diseases, and chronic inflammatory disorders. Deepening our understanding of UFSP2 activity is essential for the development of novel therapies aimed at manipulating immune responses in these disease contexts.
UFSP2: Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, an ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Belongs to the peptidase C78 family.Protein type: Protease; EC 3.4.22.-Chromosomal Location of Human Ortholog: 4q35.1Cellular Component: endoplasmic reticulum; cytoplasm; nucleusMolecular Function: protein binding; thiolester hydrolase activityBiological Process: regulation of estrogen receptor signaling pathway; proteolysisDisease: Beukes Hip Dysplasia
UniProt Protein Details:
NCBI Summary:
Like ubiquitin (see MIM 191339), ubiquitin-fold modifier-1 (UFM1; MIM 610553) must be processed by a protease before it can conjugate with its target proteins. UFSP2 is a thiol protease that specifically processes the C terminus of UFM1 (Kang et al., 2007 [PubMed 17182609]).[supplied by OMIM, Oct 2009]
