The UBXN11 Antibody (PAC013060) is a high-quality polyclonal antibody designed for research involving UBXN11, a protein involved in various cellular processes, including protein degradation and cell cycle regulation. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. It specifically binds to the UBXN11 protein, allowing for accurate detection and analysis in different cell types.UBXN11 is known for its role in protein turnover through the ubiquitin-proteasome system, as well as its involvement in cell proliferation and differentiation.
Its role in these processes makes it a key player in cellular function and has implications for research in areas such as cancer biology and neurodegenerative diseases. Understanding the function of UBXN11 is essential for unraveling its potential therapeutic implications and its contribution to various disease states.Overall, the UBXN11 Antibody is a valuable tool for researchers focusing on UBXN11 and its implications in cellular function and disease. Its high reactivity and specificity make it an ideal choice for studies in molecular biology, cell biology, and related fields.
UBX domain protein 11;UBXN11;COA-1;DKFZp686F04228;PP2243;SOC;SOCI;UBXD5 ;
UniProt Protein Function:
UBXN11: May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 AND RND3. Promotes RHOA activation mediated by GNA12 and GNA13. 8 isoforms of the human protein are produced by alternative splicing.Protein type: CytoskeletalChromosomal Location of Human Ortholog: 1p36.11Cellular Component: cytoplasm; cytoskeletonMolecular Function: protein binding; ubiquitin bindingBiological Process: proteasomal ubiquitin-dependent protein catabolic process
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymoprhic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
