The UBXN1 Antibody (PAC013059) is a polyclonal antibody designed for research involving UBXN1, a protein that plays a crucial role in various cellular processes, including protein degradation and DNA repair. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding to the UBXN1 protein, this antibody allows for the detection and analysis of UBXN1 in different cell types, making it an ideal tool for studies in molecular biology and cancer research.
UBXN1 is a vital component in the protein quality control system, aiding in the degradation of misfolded proteins and maintaining cellular homeostasis. Its involvement in DNA repair mechanisms also suggests a potential role in genomic stability and tumor suppression. Research into the function of UBXN1 is essential for understanding its impact on cellular processes and its potential as a therapeutic target in cancer and other diseases related to protein misfolding and DNA damage.
UBXN1: Ubiquitin-binding protein that interacts with the BRCA1- BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffold; Ubiquitin conjugating system; Proteasome complexChromosomal Location of Human Ortholog: 11q12.3Cellular Component: proteasome complex; cell soma; cytoplasm; dendrite; nucleusMolecular Function: ubiquitin binding; protein binding; ubiquitin protein ligase binding; polyubiquitin binding; ATPase bindingBiological Process: proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein ubiquitination; negative regulation of proteasomal ubiquitin-dependent protein catabolic process
