The TYROBP Polyclonal Antibody (CAB14794) is a valuable tool for researchers studying TYROBP, a transmembrane signaling protein involved in immune regulation and neurodegenerative diseases. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the TYROBP protein, this antibody allows for accurate detection and analysis in various cell types, making it an ideal choice for studies in immunology and neuroscience research.TYROBP, also known as DAP12, is a key adaptor protein that mediates signal transduction in immune cells, playing a crucial role in activating immune responses and regulating inflammation.
Dysregulation of TYROBP signaling has been implicated in various diseases, including Alzheimer's disease and autoimmune disorders. Therefore, studying the function of TYROBP is essential for gaining insights into these conditions and developing new therapeutic strategies.Overall, the TYROBP Polyclonal Antibody (CAB14794) is a reliable tool for researchers interested in unraveling the complex role of TYROBP in immune responses and neuroinflammation, offering potential applications in both basic research and drug development.
Product Name:
TYROBP Rabbit Polyclonal Antibody
SKU:
CAB14794
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-113 of human TYROBP (NP_003323.1).
This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
7305
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse pancreas, using TYROBP Rabbit pAb (CAB14794) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
