TYROBP Rabbit Polyclonal Antibody (CAB14794)
- SKU:
- CAB14794
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | TYROBP Rabbit Polyclonal Antibody |
SKU: | CAB14794 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-113 of human TYROBP (NP_003323.1). |
Sequence: | MGGL EPCS RLLL LPLL LAVS GLRP VQAQ AQSD CSCS TVSP GVLA GIVM GDLV LTVL IALA VYFL GRLV PRGR GAAE AATR KQRI TETE SPYQ ELQG QRSD VYSD LNTQ RPYY K |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | DAP12; KARAP; PLOSL; PLOSL1; TYROBP |
Positive Sample: | Mouse pancreas |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Single-pass type I membrane protein. |
Calculated MW: | 12kDa |
Observed MW: | 12kDa |
This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene.
Purification Method: | Affinity purification |
Gene ID: | 7305 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |