The TXN Polyclonal Antibody (CAB14793) is a high-quality research tool designed for studying Thioredoxin (TXN), a key redox regulator involved in various cellular processes. This antibody, produced in rabbits, demonstrates strong reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the TXN protein, researchers can accurately detect and analyze TXN levels in a variety of cell types, making it an essential tool for studies in biochemistry and cancer research.Thioredoxin, a small ubiquitous protein, plays a crucial role in maintaining cellular redox balance, thereby influencing cell survival, proliferation, and oxidative stress responses.
Its involvement in cell signaling pathways and metabolism makes it a promising target for investigating diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases. Understanding the functions of Thioredoxin is essential for developing targeted therapies that modulate redox signaling pathways and combat oxidative stress-related conditions.
The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
7295
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Thioredoxin 1 (Trx1/TXN) Rabbit pAb (CAB14793) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
