The TRPC4AP Antibody (PAC012939) is a valuable tool for researchers studying TRPC4AP, a protein involved in cellular processes and signaling pathways. This polyclonal antibody, produced in rabbits, is highly specific and reacts strongly with human samples, making it suitable for Western blot analysis. By binding specifically to TRPC4AP, researchers can accurately detect and quantify the protein in a variety of cell types, making it an essential tool for studies in molecular biology and cell signaling.TRPC4AP is known to play a crucial role in regulating calcium signaling and ion channel activity, making it a key player in various physiological processes.
Its involvement in cell proliferation, differentiation, and migration also highlights its significance in cancer research and drug development efforts. By understanding the function and regulation of TRPC4AP, researchers can uncover new therapeutic targets and potential treatment strategies for diseases related to aberrant calcium signaling and channel activity.
TRPC4AP: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 20q11.22Cellular Component: plasma membraneMolecular Function: calcium channel activity; phosphatase binding; protein bindingBiological Process: protein ubiquitination; ubiquitin-dependent protein catabolic process
