The TRIM36 Polyclonal Antibody (PAC040862) is a valuable tool for research involving the TRIM36 protein, a member of the tripartite motif (TRIM) protein family implicated in various cellular processes. This antibody, developed using rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically targeting the TRIM36 protein, researchers can effectively detect and analyze its expression in different cell types, making it an ideal choice for studies in molecular biology and cell signaling.TRIM36 is known to play a role in regulating cellular processes such as protein degradation, immune response, and cell differentiation.
Its association with various signaling pathways and cellular functions makes it a promising target for research into diseases like cancer, viral infections, and neurodegenerative disorders. Studying the function of TRIM36 can provide valuable insights into its role in disease progression and potential therapeutic interventions.Overall, the TRIM36 Polyclonal Antibody offers researchers a reliable tool for exploring the functions and mechanisms of the TRIM36 protein in various biological contexts. Its specificity and sensitivity make it a valuable asset for investigations into the molecular pathways involving TRIM36 and its implications in disease development and progression.
Antibody Name:
TRIM36 Antibody (PACO40862)
Antibody SKU:
PACO40862
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human E3 ubiquitin-protein ligase TRIM36 protein (70-280AA)
Immunohistochemistry of paraffin-embedded human testis tissue using PACO40862 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human brain tissue using PACO40862 at dilution of 1:100.
Background:
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization.
Synonyms:
E3 ubiquitin-protein ligase TRIM36 (EC 2.3.2.27) (RING finger protein 98) (RING-type E3 ubiquitin transferase TRIM36) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728), TRIM36, RBCC728 RNF98
UniProt Protein Function:
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization ().
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
