The Trim14 Monoclonal Antibody (PAC017253) is a valuable tool for researchers studying Trim14, a protein involved in antiviral immune responses. This antibody, produced using hybridoma technology, specifically recognizes Trim14 in human samples and is validated for use in various applications such as Western blot, immunofluorescence, and immunoprecipitation.Trim14, also known as tripartite motif-containing protein 14, plays a crucial role in the innate immune response to viral infections by promoting the production of antiviral cytokines. Its function in the immune system makes it an important target for research in virology and immunology, with potential implications for the development of antiviral therapies.
By using the Trim14 Monoclonal Antibody, researchers can detect and analyze Trim14 expression in different cell types, aiding in the understanding of its role in antiviral immunity. This antibody is a valuable tool for investigating the mechanisms underlying immune responses to viral infections and may contribute to the development of novel therapeutic strategies against viral pathogens.
Gel: 8%SDS-PAGE,Lysate: 40 μg,,Primary antibody: PACO17253(TRIM14 Antibody) at dilution 1/800 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 3 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO17253(TRIM14 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple transcript variants.
Synonyms:
tripartite motif containing 14
UniProt Protein Function:
TRIM14: Inhibits the transcriptional activity of SPI1 in a dose- dependent manner. Belongs to the TRIM/RBCC family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Transcription regulationChromosomal Location of Human Ortholog: 9q22.33Cellular Component: cytoplasm; intracellularMolecular Function: zinc ion bindingBiological Process: negative regulation of viral transcription; innate immune response; positive regulation of transcription factor activity; activation of NF-kappaB transcription factor
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
