The TRAF3IP2 Polyclonal Antibody (CAB6776) is a valuable tool for researchers studying TRAF3IP2, also known as Act1, a key regulator of immune and inflammatory responses. This antibody, developed using rabbit polyclonal technology, exhibits high reactivity with human samples and has been validated for use in Western blot applications.TRAF3IP2 is a critical signaling adaptor protein that plays a crucial role in various immune pathways, including NF-κB activation and cytokine production. Dysregulation of TRAF3IP2 has been linked to inflammatory diseases such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease, making it an attractive target for therapeutic interventions.
By specifically binding to TRAF3IP2, this polyclonal antibody enables accurate detection and analysis of the protein in a wide range of cell types, making it an indispensable tool for immunologists and researchers studying inflammatory disorders. Understanding the function and regulation of TRAF3IP2 is essential for developing novel treatments that target immune signaling pathways and combat inflammatory diseases effectively.
Product Name:
TRAF3IP2 Rabbit Polyclonal Antibody
SKU:
CAB6776
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human TRAF3IP2 (NP_671733.2).
This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene.
Purification Method:
Affinity purification
Gene ID:
10758
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using TRAF3IP2 Rabbit pAb (CAB6776) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
