The TMPRSS11B Monoclonal Antibody (PAC017286) is a valuable tool for researchers studying TMPRSS11B, a cell surface protease involved in various biological processes. Raised in mice, this antibody exhibits high specificity and sensitivity towards human samples, making it suitable for use in Western blot applications. By binding to the TMPRSS11B protein, this antibody enables precise detection and analysis in different cell types, making it an essential reagent for investigations in cell biology and disease research.
TMPRSS11B, also known as a serine protease, plays a crucial role in proteolytic processing and activation of various proteins in different cellular pathways. Its involvement in these processes makes it a potential target for studying diseases such as cancer, inflammatory disorders, and infectious diseases. Investigating the functions of TMPRSS11B is essential for advancing our understanding of disease mechanisms and developing targeted therapies for these conditions.
Antibody Name:
TMPRSS11B Antibody (PACO17286)
Antibody SKU:
PACO17286
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Fusion protein of human TMPRSS11B
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO17286(TMPRSS11B Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17286(TMPRSS11B Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
TMPRSS11B (transmembrane protease serine 11B), also known as airway trypsin-like protease 5, is a 416 amino acid, single-pass type II membrane protein that belongs to the peptidase S1 family and contains one peptidase S1 domain and one SEA domain. The gene that encodes TMPRSS11B consists of over 19,000 bases and maps to human chromosome 4q13.2. Chromosome 4 represents approximately 6% of the human genome and contains nearly 900 genes. Notably, the Huntingtin gene, which is found to encode an expanded glutamine tract in cases of Huntington's disease, is encoded by a gene that maps to chromosome 4. FGFR-3 is also encoded by a gene located on chromosome 4 and has been associated with thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer. Chromosome 4 is also tied to Ellis-van Creveld syndrome, methylmalonic acid, mia and polycystic kidney disease.
Synonyms:
transmembrane protease, serine 11B
UniProt Protein Function:
TMPRSS11B: Probable serine protease. Belongs to the peptidase S1 family.Protein type: EC 3.4.21.-; Membrane protein, integral; ProteaseChromosomal Location of Human Ortholog: 4q13.2Cellular Component: plasma membraneMolecular Function: serine-type peptidase activity
