The TMED4 Polyclonal Antibody (PAC017272) is a valuable tool for researchers studying TMED4, a protein involved in intracellular trafficking and protein sorting. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the TMED4 protein, researchers can accurately detect and analyze its expression in different cell types, making it an essential reagent for studies in cell biology and molecular biology.TMED4, also known as transmembrane p24 trafficking protein 4, plays a crucial role in the transport of proteins within cells, ensuring their proper localization and function.
Understanding the function of TMED4 is essential for uncovering its role in various cellular processes and diseases. Research on TMED4 may shed light on its involvement in conditions such as cancer, neurodegenerative disorders, and metabolic diseases.Overall, the TMED4 Polyclonal Antibody is a reliable tool for researchers interested in investigating the function and significance of TMED4 in health and disease. Its high specificity and sensitivity make it a valuable asset for advancing our understanding of intracellular trafficking mechanisms and potential therapeutic targets.
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17272(TMED4 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 8%SDS-PAGE,Lysate: 40 μg,Lane 1-5: HepG2 cells, K562 cells, Hela cells, A549 cells, Mouse intestines tissue,Primary antibody: PACO17272(TMED4 Antibody) at dilution 1/800 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17272(TMED4 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity).
Synonyms:
transmembrane emp24 protein transport domain containing 4
UniProt Protein Function:
TMED4: Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis. Belongs to the EMP24/GP25L family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Membrane protein, integral
Chromosomal Location of Human Ortholog: 7p13
Molecular Function:signal transducer activity
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade
