The TLX1 Polyclonal Antibody (CAB12861) is a valuable tool for researchers studying TLX1, a transcription factor involved in T-cell acute lymphoblastic leukemia (T-ALL). This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting.TLX1 is known for its critical role in the development of T-ALL, a type of blood cancer that affects T-cells. By targeting TLX1 with this antibody, researchers can detect and analyze the protein in different cell types, providing insights into the molecular mechanisms underlying T-ALL development.
This makes the TLX1 Polyclonal Antibody an essential resource for studies in oncology and hematological research.Understanding the functions and regulation of TLX1 is crucial for developing targeted therapies for T-ALL and improving patient outcomes. By utilizing the TLX1 Polyclonal Antibody, researchers can further unravel the complexities of T-ALL pathology and potentially identify new therapeutic strategies for this devastating disease.
Product Name:
TLX1 Rabbit Polyclonal Antibody
SKU:
CAB12861
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human TLX1 (NP_001182446.1).
This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
3195
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TLX1 Rabbit pAb (CAB12861) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
