TLR7 Rabbit Polyclonal Antibody (CAB0991)
- SKU:
- CAB0991
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | TLR7 Rabbit Polyclonal Antibody |
SKU: | CAB0991 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-230 of human TLR7 (NP_057646.1). |
Sequence: | FPKT LPCD VTLD VPKN HVIV DCTD KHLT EIPG GIPT NTTN LTLT INHI PDIS PASF HRLD HLVE IDFR CNCV PIPL GSKN NMCI KRLQ IKPR SFSG LTYL KSLY LDGN QLLE IPQG LPPS LQLL SLEA NNIF SIRK ENLT ELAN IEIL YLGQ NCYY RNPC YVSY SIEK DAFL NLTK LKVL SLKD NNVT AVPT VLPS TLTE L |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | IMD74; SLEB17; TLR7-like; TLR7 |
Positive Sample: | Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasmic vesicle, Endoplasmic reticulum membrane, Endosome, Lysosome, Single-pass type I membrane protein, phagosome. |
Calculated MW: | 121kDa |
Observed MW: | 150kDa |
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The human TLR family comprises 11 members. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. For the recognition of structural components in foreign microorganisms, the various TLRs exhibit different patterns of expression as well; in this way for example, TLR-3, -7, and -8 are essential in the recognition of single-stranded RNA viruses. TLR7 senses single-stranded RNA oligonucleotides containing guanosine- and uridine-rich sequences from RNA viruses, a recognition occuring in the endosomes of plasmacytoid dendritic cells and B cells. This gene is predominantly expressed in lung, placenta, and spleen, and is phylogenetically related and lies in close proximity to another family member, TLR8, on chromosome X.
Purification Method: | Affinity purification |
Gene ID: | 51284 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |