The TGFB1 Polyclonal Antibody (PACO30346) is a valuable tool for researchers studying TGFB1, a protein known for its role in cell growth, differentiation, and immune regulation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the TGFB1 protein, this antibody enables the detection and analysis of TGFB1 in various cell types, making it ideal for studies in immunology, cancer research, and cell signaling pathways.TGFB1, also known as transforming growth factor beta 1, is a key player in the regulation of immune responses, tissue repair, and inflammation.
Dysregulation of TGFB1 has been implicated in various diseases including cancer, fibrosis, and autoimmune disorders. By understanding the functions of TGFB1, researchers can uncover potential therapeutic targets and develop interventions to modulate its activity in disease settings.Overall, the TGFB1 Polyclonal Antibody (PACO30346) is a valuable tool for researchers interested in studying the role of TGFB1 in health and disease. Its high specificity and reliability make it a trusted reagent for a wide range of research applications.
Antibody Name:
TGFB1 Antibody (PACO30346)
Antibody SKU:
PACO30346
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Bovine
Immunogen:
Recombinant Bovine Transforming growth factor beta-1 proprotein protein (279-390AA)
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity).
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP) (). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus. Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types ().
