TGF beta Receptor II (TGFBR2) Rabbit Monoclonal Antibody (CAB19124)
The TGF-beta Receptor II Rabbit Monoclonal Antibody (CAB19124) is specifically designed for researchers studying the TGF-beta receptor pathway, a crucial signaling pathway involved in cell growth, differentiation, and immune regulation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.TGF-beta receptor II is a key player in the TGF-beta signaling pathway, which is known to have diverse roles in immune regulation, tissue development, and tumor suppression. By targeting the TGF-beta receptor II protein, this antibody enables researchers to detect and analyze its expression in various cell types, making it an essential tool for studies in immunology, cancer research, and developmental biology.
The TGF-beta receptor II Rabbit Monoclonal Antibody is particularly valuable for investigating the role of the TGF-beta pathway in diseases such as cancer, fibrosis, and autoimmune disorders. Understanding the activity of TGF-beta receptor II is essential for developing targeted therapies that manipulate this pathway for therapeutic benefit. By providing a reliable tool for detecting TGF-beta receptor II, this antibody supports advancements in research aimed at elucidating the functions of this important signaling molecule.
Product Name:
TGF beta Receptor II (TGFBR2) Rabbit Monoclonal Antibody
SKU:
CAB19124
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 23-130 of human TGF beta Receptor II (TGFBR2) (TGFBR2) (P37173).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
65kDa/67kDa/9kDa
Observed MW:
70-80kDa,90kDa
The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.
Purification Method:
Affinity purification
Gene ID:
7048
Clone Number:
ARC0407
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of Hep G2 cells, using TGF beta Receptor II (TGFBR2) (TGFBR2) antibody (CAB19124) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
