The TBX15 Polyclonal Antibody (PACO30294) is a valuable tool for researchers studying the TBX15 protein, a transcription factor involved in various biological processes, including embryonic development and tissue differentiation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.TBX15 plays a crucial role in regulating gene expression and controlling cell fate decisions, making it an important target for studies in developmental biology and regenerative medicine.
By detecting and analyzing TBX15 expression in different cell types, researchers can gain insights into its function and potential therapeutic applications in conditions such as birth defects and tissue regeneration.The TBX15 Polyclonal Antibody is a reliable tool for investigating the role of TBX15 in various biological processes, offering researchers the opportunity to advance their understanding of this key transcription factor and its implications for human health and disease.
Antibody Name:
Tbx15 Antibody (PACO30294)
Antibody SKU:
PACO30294
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Mouse
Immunogen:
Recombinant Mouse T-box transcription factor TBX15 protein (1-120AA)
Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes.
Synonyms:
T-box transcription factor TBX15 (T-box protein 15) (MmTBx8) (T-box transcription factor TBX14) (T-box protein 14), Tbx15, Tbx14 Tbx8
UniProt Protein Function:
TBX15: Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes. Defects in TBX15 are the cause of Cousin syndrome (COUSS); also known as craniofacial dysmorphism, hypoplasia of scapula and pelvis, and short stature. Cousin syndrome is defined as pelviscapular dysplasia with epiphyseal abnormalities, congenital dwarfism and facial dysmorphy (frontal bossing, hypertelorism, narrow palpebral fissures, deep set globes, strabismus, low-set posteriory rotated and unusually formed external ears, dysplasia of conchae, small chin, short neck with redundant skin folds, and a low hairline). Intelligence may vary from normal to moderately impaired. Radiographic features comprise aplasia of the body of the scapula, hypoplasia of the iliac bone, humeroradial synosthosis, dislocation of the femoral heads, and moderate brachydactyly. 2 isoforms of the human protein are produced by alternative splicing.Protein type: DNA-bindingCellular Component: nucleusMolecular Function: DNA binding; protein heterodimerization activity; protein homodimerization activity; transcription factor activityBiological Process: embryonic cranial skeleton morphogenesis; embryonic skeletal morphogenesis; regulation of transcription, DNA-dependent; transcription, DNA-dependent
