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TACC1 Antibody (PACO05161)

SKU:
PACO05161
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269

Description

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TACC1 Antibody (PACO05161)

The TACC1 Polyclonal Antibody (PACO05161) is a valuable tool for researchers studying TACC1, a protein involved in cell division and cancer development. This antibody, produced in rabbits, exhibits high reactivity with human samples and is recommended for use in Western blot applications. By specifically binding to the TACC1 protein, researchers can assess its expression levels and localization in various cell types, aiding in cancer research and understanding the mechanisms of cell division.TACC1, also known as transforming acidic coiled-coil protein 1, is a crucial player in regulating microtubule dynamics during cell division, making it a potential target for cancer therapy.

Studies have shown that dysregulation of TACC1 expression is associated with tumor development and progression, highlighting its importance in cancer biology. By utilizing the TACC1 Polyclonal Antibody, researchers can delve deeper into the molecular mechanisms underlying cancer and potentially identify novel therapeutic targets.

Antibody Name:TACC1 Antibody (PACO05161)
Antibody SKU:PACO05161
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:ELISA:1:10000, WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human, Mouse
Immunogen:Synthesized peptide derived from the N-terminal region of human TACC1.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:TACC1; KIAA1103; Transforming acidic coiled-coil-containing protein 1; Gastric cancer antigen Ga55; Taxin-1
UniProt Protein Function:TACC1: Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. Belongs to the TACC family. 8 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cytoskeletal; Cell development/differentiation

Chromosomal Location of Human Ortholog: 8p11.22

Cellular Component: cytoplasm; intermediate filament cytoskeleton; microtubule cytoskeleton

Molecular Function:protein binding

Biological Process: cell proliferation; cerebral cortex development; microtubule cytoskeleton organization and biogenesis

NCBI Summary:This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
UniProt Code:O75410
NCBI GenInfo Identifier:59800391
NCBI Gene ID:6867
NCBI Accession:O75410.2
UniProt Secondary Accession:O75410,Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2 Q8NEY7, Q9UPP9, B2RBD9, D3DSX6,
UniProt Related Accession:O75410
Molecular Weight:17,815 Da
NCBI Full Name:Transforming acidic coiled-coil-containing protein 1
NCBI Synonym Full Names:transforming acidic coiled-coil containing protein 1
NCBI Official Symbol:TACC1  
NCBI Official Synonym Symbols:Ga55  
NCBI Protein Information:transforming acidic coiled-coil-containing protein 1
UniProt Protein Name:Transforming acidic coiled-coil-containing protein 1
UniProt Synonym Protein Names:Gastric cancer antigen Ga55; Taxin-1
Protein Family:Transforming acidic coiled-coil-containing protein
UniProt Gene Name:TACC1  
UniProt Entry Name:TACC1_HUMAN

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