The SULT1B1 Polyclonal Antibody (PAC017174) is a valuable tool for researchers studying SULT1B1, a cytosolic enzyme involved in the sulfonation of xenobiotics and endogenous compounds. This antibody, produced in rabbits, exhibits high specificity and reactivity with human samples and has been validated for use in Western blot applications. By binding to the SULT1B1 protein, researchers can accurately detect and analyze this enzyme in a variety of cell types, making it an essential component for studies in drug metabolism, toxicology, and personalized medicine.
SULT1B1 plays a crucial role in the conjugation and detoxification of various compounds, including drugs, hormones, and environmental toxins. Understanding the function and regulation of SULT1B1 is essential for predicting individuals' responses to different medications and identifying potential drug interactions. By elucidating the pathways and mechanisms involving SULT1B1, researchers can develop safer and more effective therapeutic strategies for a wide range of diseases and conditions.
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal intestines tissue, Primary antibody: PACO17174(SULT1B1 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17174(SULT1B1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. However, the total genomic length of this gene is greater than that of other SULT1 genes.
Synonyms:
sulfotransferase family, cytosolic, 1B, member 1
UniProt Protein Function:
SULT1B1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine. Belongs to the sulfotransferase 1 family.
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. However, the total genomic length of this gene is greater than that of other SULT1 genes. [provided by RefSeq, Jul 2008]
