The Stat4 Polyclonal Antibody (CAB2638) is a crucial tool for researchers studying the STAT4 protein, a transcription factor involved in regulating immune responses and inflammation. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for use in Western blotting and other experimental techniques.STAT4 is known for its role in promoting the differentiation of T helper cells and driving the production of pro-inflammatory cytokines. Dysregulation of STAT4 activity has been linked to various autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, as well as certain types of cancer.
By targeting STAT4, researchers can explore potential therapeutic strategies for managing these conditions.With its ability to specifically detect and quantify STAT4 protein levels in different cell types, the Stat4 Polyclonal Antibody is an invaluable resource for investigations into immune signaling pathways and disease mechanisms. Whether studying basic immunology or exploring new treatment approaches, this antibody offers a reliable tool for advancing scientific understanding in the field.
Product Name:
STAT4 Rabbit Polyclonal Antibody
SKU:
CAB2638
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 569-748 of human STAT4 (NP_003142.1).
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.
Purification Method:
Affinity purification
Gene ID:
6775
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using STAT4 Rabbit pAb (CAB2638) at 1:3000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 90s.
