The STARD4 Polyclonal Antibody (CAB15955) is specifically designed for research involving STARD4, a protein involved in lipid transport and metabolism within cells. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the STARD4 protein, this antibody enables the detection and analysis of STARD4 in various cell types, making it ideal for studies in lipid biology and cellular metabolism research.STARD4 is a critical player in the intracellular transportation of cholesterol and other lipids, making it a key regulator of lipid homeostasis and metabolic processes.
Research into STARD4 is essential for understanding how cells regulate lipid balance and how dysregulation of lipid metabolism can lead to diseases such as atherosclerosis, obesity, and metabolic disorders. By studying STARD4, researchers can uncover potential therapeutic targets for the treatment of lipid-related disorders.
Product Name:
STARD4 Rabbit Polyclonal Antibody
SKU:
CAB15955
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human STARD4 (NP_001294986.1).
Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD4 (Soccio et al., 2002 [PubMed 12011452]).
Purification Method:
Affinity purification
Gene ID:
134429
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using STARD4 Rabbit pAb (CAB15955) at 1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
