The SRMS Polyclonal Antibody (PAC054182) is a vital tool for researchers investigating the role of SRMS, a non-receptor tyrosine kinase implicated in various cellular processes, including cell growth, differentiation, and survival. This antibody, generated in rabbits, exhibits high specificity for human SRMS and has been validated for use in Western blot assays.SRMS is known for its involvement in signaling pathways associated with cancer progression, making it a key target for studies in oncology research. By binding to SRMS, this antibody allows for the visualization and analysis of SRMS expression in different cell types, offering valuable insights into its function and potential as a therapeutic target.
Given the importance of SRMS in cancer development and progression, understanding its role and regulation is crucial for the development of novel anti-cancer therapies. The SRMS Polyclonal Antibody provides researchers with a reliable tool to investigate the intricacies of SRMS signaling pathways and its implications in cancer biology.
Immunohistochemistry analysis of human breast cancer using PACO54182 at dilution of 1:100.
Immunofluorescent analysis of MCF-7 cells using PACO54182 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. May be involved in proliferation or differentiation of keratinocytes in the skin.
SRMS: a tyrosine kinase of the Src family. Protein type: Protein kinase, tyrosine (non-receptor); Kinase, protein; EC 2.7.10.2; Motility/polarity/chemotaxis; Protein kinase, TK; TK group; Src familyChromosomal Location of Human Ortholog: -Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membraneMolecular Function: non-membrane spanning protein tyrosine kinase activity; protein binding; protein-tyrosine kinase activity; receptor bindingBiological Process: cell differentiation; cell migration; innate immune response; negative regulation of signal transduction; regulation of cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway
