The SPT16 Polyclonal Antibody (PACO30226) is a valuable tool for researchers studying the SPT16 protein, a key component of the FACT (facilitates chromatin transcription) complex involved in chromatin remodeling and transcription regulation. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blotting assays. By binding to the SPT16 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in molecular biology and gene expression.SPT16, also known as Suppressor of Ty 16, plays a crucial role in maintaining chromatin structure and facilitating transcription by RNA polymerase II.
Its involvement in gene regulation and DNA repair processes underscores its importance in cellular function and development. Research on SPT16 can provide insights into mechanisms of gene expression control, epigenetic regulation, and genome stability, with implications for understanding various diseases and advancing therapeutic strategies. Investigating the function of SPT16 with the help of this antibody can lead to valuable discoveries in the fields of genetics, oncology, and developmental biology.
Antibody Name:
SPT16 Antibody (PACO30226)
Antibody SKU:
PACO30226
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Arabidopsis thaliana
Immunogen:
Recombinant Arabidopsis thaliana FACT complex subunit SPT16 protein (890-1074AA)
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (Probable).
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (Probable).
UniProt Protein Details:
NCBI Summary:
encodes a component of the FAcilitates Chromatin Transcription (FACT) complex, SPT16.Along with SSRP1 binds to the promoter of FLC.
