The SPECC1L Polyclonal Antibody (CAB15798) is a crucial tool for researchers studying the SPECC1L protein, a key player in cell biology and development. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications including Western blot analysis. By targeting the SPECC1L protein, this antibody enables precise detection and analysis in a wide range of cell types, making it an essential component for research in fields such as cellular biology and developmental genetics.
SPECC1L, also known as sperm antigen with calponin homology and coiled-coil domains 1-like protein, is involved in critical cellular processes such as cell division, cell migration, and cytoskeleton organization. Its importance in these fundamental biological functions highlights its potential significance in various diseases and developmental disorders. By studying the role of SPECC1L, researchers can gain valuable insights into the mechanisms underlying these conditions, paving the way for novel therapeutic approaches and interventions.
Product Name:
SPECC1L Rabbit Polyclonal Antibody
SKU:
CAB15798
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 200-500 of human SPECC1L (NP_056145.4).
Cell junction, Cytoplasm, cytoskeleton, gap junction, spindle.
Calculated MW:
125kDa
Observed MW:
168kDa
This gene encodes a coiled-coil domain containing protein. The encoded protein may play a critical role in actin-cytoskeletal reorganization during facial morphogenesis. Mutations in this gene are a cause of oblique facial clefting-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A read-through transcript composed of SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and the downstream ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding.
Purification Method:
Affinity purification
Gene ID:
23384
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SPECC1L Rabbit pAb (CAB15798) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
