The SPEB Polyclonal Antibody (PACO50626) is a crucial tool for researchers studying the SPEB protein, which plays a key role in bacterial pathogenesis. This antibody, developed using rabbit immunization, is highly specific to human samples and has been rigorously validated for use in various applications, including Western blotting.SPEB, a bacterial protein, is known to be involved in the evasion of host immune responses and the establishment of bacterial infections. By targeting SPEB with this antibody, researchers can gain insights into the molecular mechanisms underlying bacterial pathogenesis and potentially identify new therapeutic targets for combating bacterial infections.
With its high reactivity and specificity, the SPEB Polyclonal Antibody is a valuable asset for studies in microbiology, infectious diseases, and antibiotic resistance research. Its ability to detect and analyze SPEB in different experimental settings makes it an essential tool for unraveling the complex interplay between bacteria and the host immune system.
Antibody Name:
speB Antibody (PACO50626)
Antibody SKU:
PACO50626
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:
Streptococcus pyogenes serotype M28
Immunogen:
Recombinant Streptococcus pyogenes serotype M28 Streptopain protein (146-398AA)
Western Blot. Positive WB detected in Recombinant protein. All lanes: speB antibody at 2.8µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 44 kDa. Observed band size: 44 kDa..
Background:
Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing (By similarity).
Synonyms:
Streptopain (EC 3.4.22.10) (Exotoxin type B) (SPE B) (Streptococcal cysteine proteinase) (Streptococcus peptidase A) (SPP), speB
UniProt Protein Function:
Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing ().
