The SP1 Polyclonal Antibody (CAB14662) is a valuable tool for researchers studying the SP1 transcription factor, a critical regulator of gene expression involved in various cellular processes. This antibody, generated in rabbits, is highly specific for SP1 and has been validated for use in immunohistochemistry and western blotting applications.SP1 is known for its role in transcriptional regulation, controlling the expression of genes involved in cell growth, differentiation, and apoptosis. Dysregulation of SP1 has been implicated in the development of cancer, inflammation, and other diseases, making it a promising target for therapeutic intervention.
By utilizing the SP1 Polyclonal Antibody, researchers can investigate the function of SP1 in different cell types and disease models, gaining valuable insights into its molecular mechanisms and potential as a therapeutic target. This antibody is a reliable tool for advancing research in the fields of oncology, immunology, and molecular biology.
Product Name:
SP1 Rabbit Polyclonal Antibody
SKU:
CAB14662
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 420-620 of human SP1 (NP_612482.2).
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6667
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse heart, using SP1 Rabbit pAb (CAB14662) at 1:600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
