The SOX8/SOX9/SOX17/SOX18 Polyclonal Antibody (PAC023234) is a powerful tool for researchers studying the SOX family of transcription factors. These proteins play essential roles in embryonic development, cell fate determination, and stem cell maintenance. The antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for use in Western blot applications.SOX8, SOX9, SOX17, and SOX18 are key regulators of gene expression, impacting various biological processes such as organogenesis, cardiovascular development, and angiogenesis. By targeting these transcription factors, researchers can gain insights into the mechanisms underlying these complex processes and their relevance in disease states.
Furthermore, aberrant expression or mutations in SOX proteins have been linked to developmental disorders, cancer, and other diseases. As such, the SOX8/SOX9/SOX17/SOX18 Polyclonal Antibody serves as a valuable tool for investigating the role of SOX proteins in normal physiology and disease pathogenesis. Its versatility and reliability make it a valuable asset for studies in developmental biology, regenerative medicine, and oncology.
Synthesized peptide derived from C-terminal of human SOX8/9/17/18.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from COS7 cells, untreated or treated with serum (10%, 30mins), using SOX8/9/17/18 antibody.
Immunohistochemistry analysis of paraffin-embedded human brain tissue using SOX8/9/17/18 antibody.
Background:
May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' By similarity.
Synonyms:
Transcription factor SOX-8/9/17/18; SOX8/9/17/18;
UniProt Protein Function:
SOX8: May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'.
UniProt Protein Details:
Protein type:DNA-binding
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: cytoplasm; nucleus
Molecular Function:DNA binding; protein heterodimerization activity; transcription factor binding
Biological Process: negative regulation of photoreceptor cell differentiation; transcription from RNA polymerase II promoter; fat cell differentiation; cell fate commitment; positive regulation of gliogenesis; in utero embryonic development; astrocyte fate commitment; positive regulation of transcription, DNA-dependent; male gonad development; cell maturation; signal transduction; Sertoli cell development; enteric nervous system development; peripheral nervous system development; osteoblast differentiation; retina development in camera-type eye; positive regulation of osteoblast proliferation; oligodendrocyte differentiation; spermatogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of myoblast differentiation; neural crest cell migration; negative regulation of apoptosis
NCBI Summary:
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome). [provided by RefSeq, Jul 2008]
