SMC1 Rabbit Polyclonal Antibody (CAB7008)
- SKU:
- CAB7008
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
Product Name: | SMC1 Rabbit Polyclonal Antibody |
SKU: | CAB7008 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human SMC1 (NP_006297.2). |
Sequence: | MGFL KLIE IENF KSYK GRQI IGPF QRFT AIIG PNGS GKSN LMDA ISFV LGEK TSNL RVKT LRDL IHGA PVGK PAAN RAFV SMVY SEEG AEDR TFAR VIVG GSSE YKIN NKVV QLHE YSEE LEKL GILI KA |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | SMC1; SMCB; CDLS2; DEE85; SB1.8; EIEE85; SMC1L1; DXS423E; SMC1alpha |
Positive Sample: | 22Rv1,NCI-H460,HeLa,293T,SKOV3,Mouse liver,Mouse spleen,Mouse pancreas,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Chromosome, Nucleus, centromere, kinetochore. |
Calculated MW: | 143kDa |
Observed MW: | 143kDa |
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 8243 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |