The SLN Antibody (PACO12318) is a high-quality polyclonal antibody designed for research involving SLN, a key protein involved in lipid metabolism and energy homeostasis. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various applications such as Western blot and immunohistochemistry.SLN, also known as sarcolipin, is a regulatory protein found in skeletal muscle that plays a crucial role in regulating the activity of the sarcoplasmic reticulum calcium ATPase (SERCA) pump.
Through its interaction with SERCA, SLN modulates calcium cycling in muscle cells, impacting muscle contraction and overall metabolism.Research into SLN has implications for understanding metabolic disorders, muscle function, and potential therapeutic targets for conditions such as obesity and heart disease. The SLN Antibody (PACO12318) offers a valuable tool for studying the expression and function of SLN in various tissues and cell types, providing insights into its role in metabolic regulation.
sarcolipin: Sarcoplasmic reticulum Ca(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of Ca(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum Ca(2+)-ATPases. The transmembrane protein interacts with Ca(2+)-ATPases and reduces the accumulation of Ca(2+) in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis. [provided by RefSeq, Jul 2008]Protein type: Endoplasmic reticulum; Membrane protein, integralChromosomal Location of Human Ortholog: 11q22.3Cellular Component: sarcoplasmic reticulum membrane; sarcoplasmic reticulum; integral to membraneMolecular Function: enzyme inhibitor activity; ATPase bindingBiological Process: calcium ion transport; negative regulation of catalytic activity; regulation of calcium ion transport; negative regulation of protein complex disassembly
UniProt Protein Details:
NCBI Summary:
Sarcoplasmic reticulum Ca(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of Ca(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum Ca(2+)-ATPases. The transmembrane protein interacts with Ca(2+)-ATPases and reduces the accumulation of Ca(2+) in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis. [provided by RefSeq, Jul 2008]
