The SLC7A11/XCT Rabbit Monoclonal Antibody (CAB2413) is a cutting-edge tool for research in the field of immunology and cancer biology. This antibody is specifically designed to target SLC7A11/XCT, a key transporter protein involved in regulating cellular redox balance and supporting tumor growth.Raised in rabbits, this monoclonal antibody is highly specific and reactive with human samples, making it ideal for various applications in research, including Western blotting, immunohistochemistry, and flow cytometry. By binding to SLC7A11/XCT, this antibody enables precise detection and analysis of this critical protein in different cell types, allowing researchers to study its role in cancer development and progression.
SLC7A11/XCT plays a crucial role in mediating the uptake of cystine, a precursor of the antioxidant glutathione, and is essential for protecting cancer cells from oxidative stress and promoting their survival. As such, this transporter protein is a promising target for the development of novel cancer therapies that exploit vulnerabilities in tumor metabolism.By using the SLC7A11/XCT Rabbit Monoclonal Antibody (CAB2413) in your research, you can gain valuable insights into the mechanisms underlying cancer cell survival and potentially identify new strategies for targeting tumor metabolism in the fight against cancer.
Antibody Name:
Anti-SLC7A11 / xCT Antibody
Antibody SKU:
CAB2413
Antibody Size:
20uL, 50uL, 100uL
Application:
WB
Reactivity:
Human, Mouse, Rat
Host Species:
Rabbit
Immunogen:
A synthesized peptide derived from human SLC7A11 / xCT
Application:
WB
Recommended Dilution:
WB 1:500 - 1:2000
Reactivity:
Human, Mouse, Rat
Positive Samples:
HeLa, 293T, HepG2, Rat liver, Rat brain, Mouse liver
Immunogen:
A synthesized peptide derived from human SLC7A11 / xCT
Purification Method:
Affinity purification
Storage Buffer:
Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:
IgG
Sequence:
Email for sequence
Gene ID:
23657
Uniprot:
Q9UPY5
Cellular Location:
Membrane, Multi-pass membrane protein
Calculated MW:
55kDa
Observed MW:
37KDa
Synonyms:
CCBR1, xCT
Background:
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]
UniProt Protein Function:
Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.
NCBI Summary:
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]
