SLC5A7 Rabbit Polyclonal Antibody (CAB8247)
- SKU:
- CAB8247
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Description
Product Name: | SLC5A7 Rabbit Polyclonal Antibody |
SKU: | CAB8247 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 503-580 of human SLC5A7 (NP_068587.1). |
Sequence: | ESGT LPPK LDVF DAVV ARHS EENM DKTI LVKN ENIK LDEL ALVK PRQS MTLS STFT NKEA FLDV DSSP EGSG TEDN LQ |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | CHT; CHT1; CMS20; HMN7A; DHMNVP; SLC5A7 |
Positive Sample: | C6,SH-SY5Y,U-251MG,SGC-7901,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Multi-pass membrane protein. |
Calculated MW: | 63kDa |
Observed MW: | 66-75kDa |
This gene encodes a sodium ion- and chloride ion-dependent high-affinity transporter that mediates choline uptake for acetylcholine synthesis in cholinergic neurons. The protein transports choline from the extracellular space into presynaptic terminals for synthesis into acetylcholine. Increased choline uptake results from increased density of this protein in synaptosomal plasma membranes in response to depolarization of cholinergic terminals. Dysfunction of cholinergic signaling has been implicated in various disorders including depression, attention-deficit disorder, and schizophrenia. An allelic variant of this gene is associated with autosomal dominant distal hereditary motor neuronopathy type VIIA. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 60482 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |