The SLC5A7 Polyclonal Antibody (CAB8247) is a valuable tool for researchers studying SLC5A7, a protein involved in neurotransmitter transport and neurological functions. This antibody, produced in rabbits, is highly specific to human samples and is suitable for use in various experimental applications, including Western blotting.SLC5A7, also known as choline transporter-like protein 1 (CTL1), plays a crucial role in the transport of choline, a necessary nutrient for neurotransmitter synthesis, across cell membranes. Dysfunction of SLC5A7 has been implicated in neurological disorders and cognitive decline, highlighting the importance of studying this protein in research settings.
By utilizing the SLC5A7 Polyclonal Antibody, researchers can accurately detect and analyze SLC5A7 protein levels in different cell types and tissues, providing insights into its function and potential implications in various neurological conditions. This antibody is a valuable tool for investigating the role of SLC5A7 in brain health and disease, paving the way for potential therapeutic interventions targeting this transporter protein.
Product Name:
SLC5A7 Rabbit Polyclonal Antibody
SKU:
CAB8247
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 503-580 of human SLC5A7 (NP_068587.1).
This gene encodes a sodium ion- and chloride ion-dependent high-affinity transporter that mediates choline uptake for acetylcholine synthesis in cholinergic neurons. The protein transports choline from the extracellular space into presynaptic terminals for synthesis into acetylcholine. Increased choline uptake results from increased density of this protein in synaptosomal plasma membranes in response to depolarization of cholinergic terminals. Dysfunction of cholinergic signaling has been implicated in various disorders including depression, attention-deficit disorder, and schizophrenia. An allelic variant of this gene is associated with autosomal dominant distal hereditary motor neuronopathy type VIIA. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
60482
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SLC5A7 Rabbit pAb (CAB8247) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
