The SLC26A3 Polyclonal Antibody (CAB6741) is a valuable tool for researchers studying SLC26A3, a protein involved in chloride and bicarbonate ion transport in the intestine. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications.SLC26A3 plays a crucial role in maintaining electrolyte balance in the intestinal tract, influencing fluid secretion and absorption. Dysregulation of SLC26A3 has been linked to various gastrointestinal disorders, making it a target of interest in research on conditions such as diarrhea, inflammatory bowel disease, and cystic fibrosis.
By specifically binding to SLC26A3, this antibody enables researchers to detect and analyze the protein in different cell types, providing valuable insights into its function and potential therapeutic applications. Its versatility and reliability make it an essential tool for studies in gastroenterology and related fields.
Product Name:
SLC26A3 Rabbit Polyclonal Antibody
SKU:
CAB6741
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 505-764 of human SLC26A3 (NP_000102.1).
The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea.
Purification Method:
Affinity purification
Gene ID:
1811
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of NCI-H125 cells, using SLC26A3 antibody (CAB6741) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
