The SLC16A8 Polyclonal Antibody (PAC020474) is a valuable tool for researchers studying SLC16A8, a member of the SLC16 family of transporters involved in the transport of monocarboxylates across cell membranes. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it suitable for a range of research applications including Western blotting.SLC16A8, also known as monocarboxylate transporter 3 (MCT3), plays a key role in the transport of important metabolites such as lactate, pyruvate, and ketone bodies.
Its function in cellular metabolism and energy production make it a promising target for research in areas such as cancer metabolism, diabetes, and neurological disorders.By enabling the detection and analysis of SLC16A8 in various cell types, this antibody provides valuable insights into the role of this transporter in health and disease. Researchers can use this tool to further understand the molecular mechanisms underlying SLC16A8 function, paving the way for potential therapeutic interventions in metabolic disorders and beyond.
Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane: Human fetal brain tissue, Primary antibody: PACO20474(SLC16A8 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20474(SLC16A8 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes. Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acid, derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.
Synonyms:
solute carrier family 16 (monocarboxylate transporter), member 8
UniProt Protein Function:
SLC16A8: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Biological Process: lactate transport; leukocyte migration; pyruvate metabolic process
NCBI Summary:
SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM, Apr 2010]
