SKP1 Rabbit Polyclonal Antibody (CAB12518)
- SKU:
- CAB12518
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | SKP1 Rabbit Polyclonal Antibody |
SKU: | CAB12518 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-163 of human SKP1 (NP_733779.1). |
Sequence: | MPSI KLQS SDGE IFEV DVEI AKQS VTIK TMLE DLGM DDEG DDDP VPLP NVNA AILK KVIQ WCTH HKDD PPPP EDDE NKEK RTDD IPVW DQEF LKVD QGTL FELI LAAN YLDI KGLL DVTC KTVA NMIK GKTP EEIR KTFN IKND FTEE EEAQ VRKE NQWC EEK |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | OCP2; p19A; EMC19; SKP1A; OCP-II; TCEB1L; SKP1 |
Positive Sample: | HeLa,293T,U-251MG,Mouse brain,Mouse heart,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | centrosome, cytoplasm, cytosol, nucleoplasm, nucleus |
Calculated MW: | 19kDa |
Observed MW: | 15-19kDa |
This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.
Purification Method: | Affinity purification |
Gene ID: | 6500 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |