SIGLEC12 Rabbit Polyclonal Antibody (CAB8519)
- SKU:
- CAB8519
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | SIGLEC12 Rabbit Polyclonal Antibody |
SKU: | CAB8519 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-210 of human SIGLEC12 (NP_443729.1). |
Sequence: | EQKD YLLT MQKS VTVQ EGLC VSVL CSFS YPQN GWTA SDPV HGYW FRAG DHVS RNIP VATN NPAR AVQE ETRD RFHL LGDP QNKD CTLS IRDT RESD AGTY VFCV ERGN MKWN YKYD QLSV NVTA SQDL LSRY RLEV PESV TVQE GLCV SVPC SVLY PHYN WTAS SPVY GSWF KEGA DIPW DIPV ATNT PSG |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | S2V; SLG; SIGLECL1; Siglec-XII; SIGLEC12 |
Positive Sample: | Mouse spleen,Mouse heart |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Single-pass type I membrane protein. |
Calculated MW: | 65kDa |
Observed MW: | 80kDa |
Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 89858 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |