The Shox2 Polyclonal Antibody (CAB8309) is a valuable tool for researchers studying the Shox2 protein, a transcription factor involved in embryonic development and stem cell differentiation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in applications such as immunofluorescence and immunohistochemistry.Shox2 plays a crucial role in various cellular processes, including skeletal development and cardiac function. Dysregulation of Shox2 expression has been linked to developmental disorders and certain types of cancer.
By detecting and analyzing the Shox2 protein, researchers can gain insights into its functions and mechanisms, paving the way for potential therapeutic interventions in related diseases.With its specificity and sensitivity, the Shox2 Polyclonal Antibody is an essential tool for investigating the role of Shox2 in both normal development and disease pathology. Its versatility in different experimental techniques makes it a valuable resource for researchers in the fields of developmental biology, regenerative medicine, and oncology.
Product Name:
SHOX2 Rabbit Polyclonal Antibody
SKU:
CAB8309
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 96-355 of human SHOX2 (NP_003021.3).
This gene is a member of the homeobox family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeobox genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeobox genes. This locus represents a pseudoautosomal homeobox gene that is thought to be responsible for idiopathic short stature, and it is implicated in the short stature phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
6474
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using SHOX2 Rabbit pAb (CAB8309) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
