The SH3BGRL3 Polyclonal Antibody (PAC041602) is a valuable tool for researchers investigating SH3BGRL3, a novel oncogene associated with cancer development and progression. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for Western blot applications. By targeting the SH3BGRL3 protein, this antibody enables precise detection and analysis in various cell types, facilitating detailed studies in the fields of oncology and cancer research.
SH3BGRL3, a member of the SH3BGRL family, has been implicated in promoting cell proliferation, survival, and metastasis in cancer cells. Its role as an oncogene makes it a promising target for therapeutic strategies aimed at inhibiting tumor growth and metastatic spread. Research into the mechanisms underlying SH3BGRL3's oncogenic properties is essential for the development of targeted cancer therapies that can effectively disrupt its pro-tumorigenic functions.
Western blot. All lanes: SH3BGRL3 antibody at 0.05µg/ml + U87 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 11 kDa. Observed band size: 11 kDa.
Immunohistochemistry of paraffin-embedded human thymus tissue using PACO41602 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO41602 at dilution of 1:100.
Background:
Could act as a modulator of glutaredoxin biological activity.
Synonyms:
SH3 domain-binding glutamic acid, rich-like protein 3 (SH3 domain-binding protein 1) (SH3BP-1), SH3BGRL3
UniProt Protein Function:
SH3BGRL3: Could act as a modulator of glutaredoxin biological activity. Belongs to the SH3BGR family.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 1p36.11Cellular Component: lamellipodiumMolecular Function: GTPase activator activity; semaphorin receptor bindingBiological Process: positive regulation of GTPase activity; regulation of actin cytoskeleton organization and biogenesis; regulation of actin filament depolymerization; regulation of blood vessel endothelial cell migration
