The Alpha-1 Antitrypsin Polyclonal Antibody (CAB1015) is a vital tool for researchers studying alpha-1 antitrypsin, a protein with important roles in protecting the lungs from damage caused by enzymes released by inflammatory cells. This polyclonal antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an excellent choice for Western blot applications.Alpha-1 antitrypsin deficiency is a genetic disorder that can lead to lung and liver diseases, making the study of this protein crucial for understanding and developing treatments for these conditions.
The Alpha-1 Antitrypsin Polyclonal Antibody (CAB1015) enables researchers to accurately detect and analyze alpha-1 antitrypsin in various cell types, advancing research in respiratory and liver diseases.By providing a reliable tool for the detection and analysis of alpha-1 antitrypsin, the Alpha-1 Antitrypsin Polyclonal Antibody (CAB1015) facilitates investigation into disease mechanisms and potential therapeutic targets, ultimately driving advancements in medical research and patient care.
The protein encoded by this gene is a serine protease inhibitor belonging to the serpin superfamily whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. This protein is produced in the liver, the bone marrow, by lymphocytic and monocytic cells in lymphoid tissue, and by the Paneth cells of the gut. Defects in this gene are associated with chronic obstructive pulmonary disease, emphysema, and chronic liver disease. Several transcript variants encoding the same protein have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5265
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Alpha-1 Antitrypsin (SERPINA1) Rabbit pAb (CAB1015) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
