The SERP1 Polyclonal Antibody (PAC014901) is a essential tool for researchers studying the role of the SERP1 protein in cellular processes. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. It binds to the SERP1 protein, allowing for accurate detection and analysis in a variety of cell types, making it an excellent choice for studies in molecular biology and disease research.SERP1, also known as Stress-associated endoplasmic reticulum protein 1, is involved in the cellular stress response and protein folding in the endoplasmic reticulum. By understanding the function of SERP1, researchers can gain insight into how cells respond to stress and maintain protein homeostasis.
This knowledge is crucial for developing targeted therapies for diseases related to protein misfolding and ER stress, such as neurodegenerative disorders and metabolic diseases. Overall, the SERP1 Polyclonal Antibody is a valuable tool for researchers investigating the role of SERP1 in cellular function and disease pathogenesis. Its high specificity and sensitivity make it a reliable choice for studying the mechanisms underlying protein folding and stress response in the endoplasmic reticulum.
Antibody Name:
SERP1 Antibody (PACO14901)
Antibody SKU:
PACO14901
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human SERP1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14901(SERP1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14901(SERP1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins.
Synonyms:
stress-associated endoplasmic reticulum protein 1
UniProt Protein Function:
RAMP4: Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins. Belongs to the RAMP4 family.Protein type: Chaperone; Membrane protein, integralChromosomal Location of Human Ortholog: 3q25.1Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; cytoplasmic microtubule; integral to membrane; ribosomeBiological Process: positive regulation of translation; unfolded protein response; multicellular organismal aging; protein modification process; positive regulation of insulin secretion; protein amino acid glycosylation; glucose metabolic process; positive regulation of organ growth; post-embryonic development; positive regulation of growth hormone secretion; protein transport; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; plasma membrane organization and biogenesis; response to stress; skeletal development; muscle morphogenesis
