SERCA2/ATP2A2 Rabbit Monoclonal Antibody (CAB11692)
- SKU:
- CAB11692
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | SERCA2/ATP2A2 Rabbit Monoclonal Antibody |
SKU: | CAB11692 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 943-1042 of human SERCA2/ATP2A2 (P16615). |
Sequence: | HFLI LYVE PLPL IFQI TPLN VTQW LMVL KISL PVIL MDET LKFV ARNY LEPG KECV QPAT KSCS FSAC TDGI SWPF VLLI MPLV IWVY STDT NFSD MFWS |
Tested Applications: | WB IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | DD; DAR; ATP2B; SERCA2; SERCA2/ATP2A2 |
Positive Sample: | 293T,NIH/3T3,RD,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum membrane, Multi-pass membrane protein, Sarcoplasmic reticulum membrane. |
Calculated MW: | 115kDa |
Observed MW: | 100kDa |
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of the skeletal muscle. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Other types of mutations in this gene have been associated with various forms of muscular dystrophies. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 488 |
Clone Number: | ARC0679 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |