The SERCA2 Rabbit Monoclonal Antibody is a high-quality antibody designed for research involving SERCA2, a crucial calcium pump protein found in the sarcoplasmic reticulum of muscle cells. This monoclonal antibody, produced in rabbits, is highly specific and reactive with human samples, making it a reliable tool for various research applications.SERCA2 plays a vital role in muscle contraction and relaxation by regulating calcium levels within the cell. Dysregulation of SERCA2 has been linked to various diseases, including heart failure, muscular dystrophy, and neurodegenerative disorders. By targeting SERCA2 with this monoclonal antibody, researchers can study its expression, localization, and function in different cell types and tissues.
Validated for use in techniques such as Western blotting, immunofluorescence, and immunohistochemistry, this antibody enables precise detection and analysis of SERCA2 protein levels. Its high specificity and sensitivity make it an ideal tool for studying the role of SERCA2 in normal physiological processes and disease states.Overall, the SERCA2 Rabbit Monoclonal Antibody is a valuable asset for researchers interested in understanding the molecular mechanisms involving SERCA2 and its implications in muscle function, cardiovascular health, and various pathological conditions.
Product Name:
SERCA2/ATP2A2 Rabbit Monoclonal Antibody
SKU:
CAB11692
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 943-1042 of human SERCA2/ATP2A2 (P16615).
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of the skeletal muscle. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Other types of mutations in this gene have been associated with various forms of muscular dystrophies. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
488
Clone Number:
ARC0679
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using SERCA2/ATP2A2 Rabbit mAb (CAB11692) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
