The SDHA Polyclonal Antibody (CAB2594) is a valuable tool for researchers studying SDHA, a crucial enzyme involved in the citric acid cycle and electron transport chain in mitochondria. This antibody, developed for use in Western blot applications, is raised in rabbits and exhibits high reactivity with human samples.SDHA, also known as succinate dehydrogenase complex subunit A, plays a key role in cellular energy production and metabolism. Dysfunction of SDHA has been implicated in various diseases, including metabolic disorders and cancer. By targeting the SDHA protein, researchers can investigate its expression levels and localization in different cell types, aiding in the understanding of its role in disease pathogenesis.
With its specificity and reliability in detecting SDHA, the CAB2594 antibody is an essential tool for researchers exploring the functions and implications of this enzyme in various biological processes. Its use in immunohistochemistry and other techniques makes it a versatile option for studies in areas such as biochemistry, cell biology, and cancer research.
Product Name:
SDHA Rabbit Polyclonal Antibody
SKU:
CAB2594
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 385-664 of human SDHA (NP_004159.2).
This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6389
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using SDHA Rabbit pAb (CAB2594) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
