The SCAP Polyclonal Antibody (PAC012040) is a valuable tool for researchers studying the SCAP protein, a key player in cholesterol metabolism and regulation. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to SCAP, this antibody allows for the accurate detection and analysis of the protein in various cell types, making it an essential component for studies in lipid metabolism, cardiovascular disease, and other related fields.SCAP, also known as SREBP cleavage-activating protein, is a crucial regulator of cholesterol biosynthesis and homeostasis. Its role in controlling the activation of SREBPs, which are transcription factors involved in lipid metabolism, highlights its importance in maintaining cellular lipid levels.
Dysregulation of SCAP has been linked to disorders such as hypercholesterolemia and atherosclerosis, making it a promising target for therapeutic interventions aimed at managing cardiovascular risk factors.Research into the function and regulation of SCAP is vital for understanding the complexities of cholesterol metabolism and its implications for human health. The SCAP Polyclonal Antibody provides researchers with a reliable tool for investigating the role of SCAP in disease processes and developing potential treatments targeting lipid-related disorders.
SCAP: Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Belongs to the WD repeat SCAP family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 3p21.31Cellular Component: Golgi membrane; Golgi apparatus; endoplasmic reticulum membrane; protein complex; endoplasmic reticulum; integral to membraneMolecular Function: protein binding; unfolded protein binding; cholesterol binding; protein complex bindingBiological Process: cholesterol metabolic process; regulation of fatty acid biosynthetic process; response to hypoxia; positive regulation of low-density lipoprotein receptor biosynthetic process; SREBP-mediated signaling pathway; negative regulation of cholesterol biosynthetic process; response to insulin stimulus; aging
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis. [provided by RefSeq, Jul 2008]
sterol regulatory element-binding protein cleavage-activating protein
NCBI Synonym Full Names:
SREBF chaperone
NCBI Official Symbol:
SCAPÂ Â
NCBI Official Synonym Symbols:
NCBI Protein Information:
sterol regulatory element-binding protein cleavage-activating protein; SREBP cleavage-activating protein; sterol regulatory element binding protein cleavage-activating protein
UniProt Protein Name:
Sterol regulatory element-binding protein cleavage-activating protein
UniProt Synonym Protein Names:
Protein Family:
Sterol regulatory element-binding protein cleavage-activating protein
