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RUNX1T1 Rabbit Polyclonal Antibody (CAB1737)

SKU:
CAB1737
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:RUNX1T1 Rabbit Polyclonal Antibody
SKU:CAB1737
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 250-403 of human RUNX1T1 (NP_783552.1).
Sequence:ENGF DREP LHSE HPSK RPCT ISPG QRYS PNNG LSYQ PNGL PHPT PPPP QHYR LDDM AIAH HYRD SYRH PSHR DLRD RNRP MGLH GTRQ EEMI DHRL TDRE WAEE WKHL DHLL NCIM DMVE KTRR SLTV LRRC QEAD REEL NYWI RRYS DAED LK
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:CDR; ETO; MTG8; AML1T1; ZMYND2; CBFA2T1; AML1-MTG8; RUNX1T1
Positive Sample:Rat brain
Conjugate:Unconjugated
Cellular Localization:Nucleus.
Calculated MW:68kDa
Observed MW:68kDa

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:862
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of Rat brain, using RUNX1T1 antibody (CAB1737) at 1:600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.

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