The RS1 Polyclonal Antibody (PACO29652) offered by Assay Genie is a valuable tool for researchers studying RS1, a protein involved in retinoschisis, a genetic eye disorder. This antibody, produced in rabbits, has high specificity and sensitivity for detecting RS1 in human samples, making it ideal for use in Western blot applications. By targeting the RS1 protein, researchers can gain insights into the mechanisms underlying retinoschisis and potentially develop targeted therapies for this condition.Retinoschisis is characterized by the splitting of the retinal layers, leading to vision impairment and potential blindness. RS1 is known to play a crucial role in maintaining the structural integrity of the retina, and mutations in the RS1 gene have been linked to the development of retinoschisis.
By studying RS1 with the PACO29652 antibody, researchers can further our understanding of the disease pathology and identify potential drug targets for intervention. Overall, the RS1 Polyclonal Antibody (PACO29652) is a valuable resource for researchers working in the field of ophthalmology and molecular biology, providing a reliable tool for studying the role of RS1 in retinoschisis and advancing potential therapies for this debilitating eye disorder.
Antibody Name:
RS1 Antibody (PACO29652)
Antibody SKU:
PACO29652
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human Retinoschisin protein (24-224AA)
Binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides (). May play a role in cell-cell adhesion processes in the retina, via homomeric interaction between octamers present on the surface of two neighboring cells (PubMed:27114531). Required for normal structure and function of the retina (PubMed:19093009).
UniProt Protein Details:
NCBI Summary:
This gene encodes an extracellular protein that plays a crucial role in the cellular organization of the retina. The encoded protein is assembled and secreted from photoreceptors and bipolar cells as a homo-oligomeric protein complex. Mutations in this gene are responsible for X-linked retinoschisis, a common, early-onset macular degeneration in males that results in a splitting of the inner layers of the retina and severe loss in vision. [provided by RefSeq, Oct 2008]
